Intracellular Cytokine Profiles of Cord and Adult Blood Lymphocytes
نویسنده
چکیده
important genetic-environmental interaction. Blood 91:4158, 1998 2. Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, Selhub J, Rozen R: Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 93:7, 1996 3. Verhoef P, Kok FJ, Kluijtmans LAJ, Blom HJ, Refsum H, Ueland PM, Kruyssen DACM: The 677 C = T mutation in the methylenetetrahydrofolate reductase gene: Associations with plasma total homocysteine levels and risk of coronary atherosclerotic disease. Atherosclerosis 132:105, 1997 4. Cattaneo M, Tsai MY, Bucciarelli P, Taioli E, Zighetti M, Bignell M, Mannucci PM: A common mutation in the methylenetetrahydrofolate reductase gene (C677T) increases the risk for deep-vein thrombosis in patients with mutant factor V (Factor V:Q506). Arterioscler Thromb Vasc Biol 17:1662, 1997 5. Legnani C, Palareti G, Grauso F, Sassi S, Grossi G, Piazzi S, Bernardi F, Marchetti G, Ferraresi P, Coccheri S: Hyperhomocyst(e)inemia and a common methylenetetrahydrofolate reductase mutation (Ala223Val MTHFR) in patients with inherited thrombophilic coagulation defects. Arterioscler Thromb Vasc Biol 17:12924, 1997 6. Stampfer MJ, Willer WC: Homocysteine and marginal vitamin deficiency. The importance of adequate vitamin intake. JAMA 270: 2726, 1993 7. Selhub J, Miller JW: The pathogenesis of homocysteinemia: Interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine. Am J Clin Nutr 55:131, 1992 8. Bostom AG, Jacques PF, Nadeau MR, Williams RR, Ellison RC, Selhub J: Post-methionine loading hyperhomocysteinemia in persons with normal fasting total plasma homocysteine: Initial results from the NHLBI Family Heart Study. Atherosclerosis 116:147, 1995 9. Girelli D, Friso S, Olivieri O, Russo C, Trabetti E, Pessotto R, Faccini G, Zenari ML, Grazioli S, Minguzzi D, Pignatti PF, Mazzucco A, Corrocher R: Post-methionine loading hyperhomocysteinemia in patients with angiographically documented coronary artery disease. Br J Haematol 102:251, 1998
منابع مشابه
Intracellular cytokine profile of cord and adult blood lymphocytes.
Umbilical cord blood (CB) transplantation is thought to be associated with a reduced risk of severe graft-versus-host-disease (GVHD) compared with bone marrow transplantation (BMT). The cytokine cascade is known to be important in the pathogenesis of GVHD; however, previous studies investigating the cytokine secretion pattern of CB cells have been contradictory because of variations in experime...
متن کاملRAPID COMMUNICATION Intracellular Cytokine Profile of Cord and Adult Blood Lymphocytes
Umbilical cord blood (CB) transplantation is thought to be associated with a reduced risk of severe graft-versus-hostdisease (GVHD) compared with bone marrow transplantation (BMT). The cytokine cascade is known to be important in the pathogenesis of GVHD; however, previous studies investigating the cytokine secretion pattern of CB cells have been contradictory because of variations in experimen...
متن کاملComparison of Functional Competence of Umbilical Cord and Adult Peripheral Blood Dendritic Cells in Allogenic Mixed Leukocyte Reaction
Background: Dendritic cells (DCs) are the most potent stimulators of primary T cell responses and play a key role in immune reactions after stem cell transplantation. Very little is known about the cord blood (CB) dendritic cells and their potential involvement in the low incidence and lower severity of acute graft-versus-host disease after CB transplantation. Objectives: The aim of this stud...
متن کاملInability of activated cord blood T lymphocytes to perform Th1-like and Th2-like responses: implications for transplantation.
Cytokines secreted by alloreactive donor T cells play a crucial role in the pathogenesis of both acute and chronic GvHD, a complication of allogeneic hematopoietic transplants that occurs at a lower incidence and severity when human umbilical cord blood (HUCB) is used. Our five-dimensional flow cytometric study performed on 20 HUCB and 20 peripheral blood (PB) samples from healthy adults was fo...
متن کاملInefficient phospholipase C activation and reduced Lck expression characterize the signaling defect of umbilical cord T lymphocytes.
Adult and neonatal immunocompetent cells exhibit important functional distinctions, including differences in cytokine production and susceptibility to tolerance induction. We have investigated the molecular features that characterize the immune response of cord blood-derived T lymphocytes compared with that of adult T lymphocytes. Our findings demonstrate that phospholipase C (PLC) isozymes, wh...
متن کاملCord blood monocyte subsets are similar to adult and show potent peptidoglycan-stimulated cytokine responses.
Human monocytes can be divided into two major subpopulations, CD14(++) CD16(-) and CD14(+) CD16(+) cells, which are suggested to play different roles in antimicrobial responses. In neonates, characteristics and functional responses of monocyte subsets have not previously been explored, and might contribute to the qualitative difference between neonatal and adult cytokine profiles. We report tha...
متن کامل